Machete is based on the "fake" trailer in Robert Rodriguez's 2007 Grindhouse, featuring Danny Trejo and Jeff Fahey reprising their original roles.

The feature version of the trailer finds Machete (Trejo) a renegade former Mexican Federale, roaming the streets of Texas after a shakedown from drug lord Torrez (Steven Seagal). Reluctantly, Machete takes an offer from spin doctor Benz (Fahey) to assassinate McLaughlin (Robert De Niro) a corrupt Senator. Double crossed and on the run Machete braves the odds with the help of Luz (Michelle Rodriguez), a saucy taco slinger, Padre (Cheech Marin) his "holy" brother, and April (Lindsay Lohan) a socialite with a penchant for guns. All while being tracked by Sartana (Jessica Alba), a sexy ICE agent with a special interest in the blade slinger.